Höfling C, Roßner S, Flachmeyer B, Krueger M, Härtig W, Michalski D.

Tricellulin, α-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia.

Int J Mol Sci 2023; 24(15): 11893

DOI: 10.3390/ijms241511893 

Barendrecht S, Schreurs A, Geissler S, Sabanov V, Ilse V, Rieckmann V, Eichentopf R, Künemund A, Hietel B, Wussow S, Hoffmann K, Körber-Ferl K, Pandey R, Carter G.W, Demuth HU, Holzer M, Roßner S, Schilling S, Preuss C, Balschun D, Cynis H.

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidodis in 5xFAD mice. 

Alzheimers Res Ther. 2023; 15(1): 16

DOI: 10.1186/s13195-022-01144-y 


Grochowska KM, Gomes GM, Raman R, Kaushik R, Sosulina L, Kaneko H, Oelschlegel AM, Yuanxiang P, Reyes-Resina I, Bayraktar G, Samer S, Spilker C, Woo MS, Morawski M, Goldschmidt J, Friese MA, Roßner S, Navarro G, Remy S, Reissner C, Karpova A, Kreutz MR.

Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease.  

EMBO J. 2023; 42(4): e112453

DOI: 10.15252/embj.2022112453



Bluhm A, Schrempel S, Moceri S, Stieler J, Feja M, Schilling S, Schulze A, von Hörsten S, Hartlage-Rübsamen M, Richter F, Roßner S

Alpha synuclein processing by MMP-3 - implications for synucleinopathies. 

Behav Brain Res. 2022; 434: 114020 

DOI: 10.1016/j.bbr.2022.114020 


Bluhm A, Schrempel S, Schilling S, von Hörsten S, Schulze A, Roßner S, Hartlage-Rübsamen M

Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer's Disease and Its Tg2576 Mouse Model. 

Biomolecules 2022; 12(7): 1006 

DOI: 10.3390/biom12071006 


Ilse V, Scholz R, Wermann M, Naumann M, Staege MS, Roßner S, Cynis H. 

Immunogenicity of the Envelope Surface Unit of Human Endogenous Retrovirus K18 in Mice. 

Int J Molec Sci. 2022; 23: 8330 

DOI: 10.3390/ijms23158330 


Klose J, Griehl C, Roßner S, Schilling S. 

Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review 

Biomolecules 2022; 12(5): 694 

DOI: 10.3390/biom12050694 



Bluhm A, Schrempel S, von Hörsten S, Schulze A, Roßner S

Proteolytic α-Synuclein Cleavage in Health and Disease. 

Int J Mol Sci. 2021; 22(11): 5450 

DOI: 10.3390/ijms22115450 


Frühauf M, Zeitschel U, Höfling C, Ullm F, Rabiger FV, Alber G, Pompe T, Müller U, Roßner S

Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture. 

Eur J Neurosci. 2021; 53(12): 4034-4050 

DOI: 10.1111/ejn.14978 


Hartlage-Rübsamen M, Bluhm A, Moceri S, Machner L, Köppen J, Schenk J, Hilbrich I, Holzer M, Weidenfeller M,  Richter F,  Coras R, Serrano GE, Beach TG, Schilling S, von Hörsten S, Xiang W, Schulze A, Roßner S
A glutaminyl cyclase-catalyzed a-synuclein modification identified in human synucleinopathies. 

Acta Neuropathol. 2021; 142(3): 399-421 

DOI: 10.1007/s00401-021-02349-5 


Berger C, Heyne HO, Heiland T, Dommel S, Höfling C, Guiu-Jurado E, Lorenz J, Roßner S, Dannemann M, Kelso J, Kovacs P, Blüher M, Klöting N. 

A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Leprdb/db mice. 

J Lipid Res. 2021; 62: 100105. 

DOI: 10.1016/j.jlr.2021.100105 


Eeza MNH, Singer R, Höfling C, Matysik J, de Groot HJM, Roβner S, Alia A. 

Metabolic Profiling of Suprachiasmatic Nucleus Reveals Multifaceted Effects in an Alzheimer's Disease Mouse Model. 

J Alzheimers Dis 2021; 81(2): 797-808 

DOI: 10.3233/JAD-201575 


Kara F, Belloy ME, Voncken R, Sarwari Z, Garima Y, Anckaerts C, Langbeen A, Leysen V, Shah D, Jacobs J, Hamaide J, Bols P, Van Audekerke J, Daans J, Guglielmetti C, Kantarci K, Prevot V, Roßner S, Ponsaerts P, Van der Linden A, Verhoye M. 

Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer’s disease. 

Neurobiol Aging 2021; 102: 139-150 

DOI: 10.1016/j.neurobiolaging.2021.02.011 


Schwarze B, Korn A, Höfling C, Zeitschel U, Krueger M, Roßner S, Huster D. 

Peptide backbone modifications of amyloid β (1-40) impact fibrillation behavior and neuronal toxicity. 

Sci Rep. 2021; 11(1): 23767 

DOI: 10.1038/s41598-021-03091-4 


Gnoth K, Piechotta A, Kleinschmidt M, Konrath S, Schenk M, Taudte N, Ramsbeck D, Rieckmann V, Geissler S, Eichentopf R, Barendrecht S, Hartlage-Rübsamen M, Demuth HU, Roßner S, Cynis H, Rahfeld JU and Schilling S.

Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology. 

Alzheimer's Research & Therapy 2020, 12: 149 

DOI: 10.1186/s13195-020-00719-x 


Gröger V, Wieland L, Naumann M 1, Meinecke AC, Meinhardt B, Roßner S, Ihling C, Emmer A, Staege MS, Cynis H.

Formation of HERV-K and HERV-Fc1 Envelope Family Members is Suppressed on Transcriptional and Translational Level.

Int. J. Mol. Sci. 2020; 21(21): 7855

DOI: 10.3390/ijms21217855 


Köppen J, Schulze A, Machner L, Wermann M, Eichentopf R, Guthardt M, Hähnel A, Klehm J, Kriegeskorte MC, Hartlage-Rübsamen M, Morawski M, von Hörsten S, Demuth HU, Roßner S, Schilling S.

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro.

Molecules 2020; 25(3): pii: E580

DOI: 10.3390/molecules25030580 


Korn A, Höfling C, Zeitschel U, Krueger M, Roßner S, Huster D.

Incorporation of the Nonproteinogenic Amino Acid β-Methylamino-alanine Affects Amyloid β Fibril Properties and Toxicity.

ACS Chem Neurosci 2020; 11(7): 1038-1047

DOI: 10.1021/acschemneuro.9b00660 



Hartlage-Rübsamen M, Ratz V, Zeitschel U, Finzel L, Machner L, Köppen J, Schulze A, Demuth HU, von Hörsten S, Höfling C, Roßner S

Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer's disease. 

Acta Neuropathol Commun. 2019; 7(1): 79 

DOI: 10.1186/s40478-019-0726-2 


Heiland T, Zeitschel U, Puchades MA, Kuhn PH, Lichtenthaler SF, Bjaalie JG, Hartlage-Rübsamen M, Roßner S, Höfling C

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain. 

Glia 2019; 67(2): 393-403 

DOI: 10.1002/glia.23550 


Höfling C, Shehabi E, Kuhn PH, Lichtenthaler SF, Hartlage-Rübsamen M, Roßner S

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease. 

Front. Neurosci 2019; 13: 137 

DOI: 10.3389/fnins.2019.00137 


Belloy ME, Shah D, Abbas A, Kashyap A, Roßner S, Van der Linden A, Keilholz SD, Keliris GA, Verhoye M. 

Author Correction: Quasi-Periodic Patterns of Neural Activity improve Classification of Alzheimer's Disease in Mice. 

Sci Rep. 2019; 9(1): 16732 

DOI: 10.1038/s41598-019-53432-7 


Roy U, Heredia-Muñoz MT, Stute L, Höfling C, Matysik J, Meijer JH, Roßner S, Alia A. 

Degeneration of the Suprachiasmatic Nucleus in an Alzheimer's Disease Mouse Model Monitored by in vivo Magnetic Resonance Relaxation Measurements and Immunohistochemistry. 

J Alzheimers Dis. 2019; 69(2): 363-375 

DOI: 10.3233/JAD-190037 


Yates SC, Groeneboom NE, Coello C, Lichtenthaler SF, Kuhn PH, Demuth HU, Hartlage-Rübsamen M, Roßner S, Leergaard T, Kreshuk A, Puchades MA, Bjaalie JG. 

QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain. 

Front Neuroinform. 2019; 13: 75 

DOI: 10.3389/fninf.2019.00075 


Hartlage-Rübsamen M, Bluhm A, Piechotta A, Linnert M, Rahfeld JU, Demuth HU, Lues I, Kuhn PH, Lichtenthaler SF, Roßner S, Höfling C.

Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation.

Molecules 2018; 23(4): 924

DOI: 10.3390/molecules23040924 


Alia A, Roßner S.

Gender, GABAergic dysfunction and AD.

Aging (Albany NY). 2018; 10(12): 3636-3637

DOI: 10.18632/aging.101672


Belloy ME, Shah D, Abbas A, Kashyap A, Roßner S, Van der Linden A, Keilholz SD, Keliris GA, Verhoye M.

Quasi-Periodic Patterns of Neural Activity improve Classification of Alzheimer's Disease in Mice.

Sci Rep. 2018; 8(1): 10024

DOI: 10.1038/s41598-018-28237-9 


Roy U, Stute L, Höfling C, Hartlage-Rübsamen M, Matysik J, Roßner S, Alia A.

Sex- and age-specific modulation of brain GABA levels in a mouse model of Alzheimer's disease.

Neurobiol Aging 2018; 62: 168-179

DOI: 10.1016/j.neurobiolaging.2017.10.015 


Schlenzig D, Cynis H, Hartlage-Rübsamen M, Zeitschel U, Menge K, Fothe A, Ramsbeck D, Spahn C, Wermann M, Roßner S, Buchholz M, Schilling S, Demuth HU.

Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation.

J Alzheimers Dis. 2018; 66(1): 359-375

DOI: 10.3233/JAD-171183 


Unger MS, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar AA, Roßner S, Heneka MT, Couillard-Despres S, Rockenstein E, Masliah E, Attems J, Aigner L.

Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?

Alzheimers Dement 2018; 14(8): 1022-1037

DOI: 10.1016/j.jalz.2018.02.017 



Scheidt HA, Adler J, Zeitschel U, Höfling C, Korn A, Krueger M, Roßner S, Huster D
Pyroglutamate-Modified Amyloid? (11- 40) Fibrils Are More Toxic than Wildtype Fibrils but Structurally Very Similar.
Chemistry 2017; 23(62): 15834-15838
DOI: 10.1002/chem.201703909 



Höfling C, Kulesskaya N, Jaako K, Peltonen I, Männistö PT, Nurmi A, Vartiainen N, Morawski M, Zharkovsky A, Võikar V, Roßner S, García-Horsman JA. 

Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume. 

Eur Neuropsychopharmacol 2016; 26: 1048-1061 

DOI: 10.1016/j.euroneuro.2016.02.015 


Höfling C, Morawski M, Zeitschel U, Zanier ER, Moschke K, Serdaroglu A, Canneva F, von Hörsten S, De Simoni MG, Forloni G, Jäger C, Kremmer E, Roßner S, Lichtenthaler SF, Kuhn PH. 

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies. 

Aging Cell 2016, 15(5): 953-963 

DOI: 10.1111/acel.12508Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, Stephan A, 


Bäuscher C, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, Plank AC, Roßner S, von Hörsten S, Graubner S, Demuth HU, Schilling S 

IsoQC (QPCTL) knockout mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes. 

Biol Chem 2016; 397(1): 45-55 

DOI: 10.1515/hsz-2015-0192 


Jaako K, Waniek A, Parik K, Klimaviciusa L, Aonurm-Helm A, Noortoots A, Anier K, Van Elzen R, Gérard M, Lambeir AM, Roßner S, Morawski M, Zharkovsky A. 

Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro. 

J Cell Sci 2016; 129(20): 3792-3802 

DOI: 10.1242/jcs.181891 


Shah D, Praet J, Latif Hernandez A, Höfling C, Anckaerts C, Bard F, Morawski M, Detrez JR, Prinsen E, Villa A, De Vos WH, Maggi A, D'Hooge R, Balschun D, Roßner S, Verhoye M, Van der Linden A. 

Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition. 

Alzheimers & Dementia 2016; 12: 964-976 

DOI: 10.1016/j.jalz.2016.03.010 


Unger MS, Marschallinger J, Kaindl J, Höfling C, Roßner S, Heneka MT, Van der Linden A, Aigner L. 

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease. 

Mol Neurobiol. 2016; 53(8): 5796-5806 

DOI: 10.1007/s12035-016-0018-9 



Hartlage-Rübsamen M, Waniek A, Meißner J, Morawski M, Schilling S, Jäger C, Kleinschmidt M, Cynis H, Kehlen A, Arendt T, Demuth HU, Roßner S

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease. 

Acta Neuropathol. 2015; 129(4): 565-583 

DOI: 10.1007/s00401-015-1395-2 


Waniek A, Hartlage-Rübsamen M, Höfling C, Kehlen A, Schilling S, Demuth HU, Roßner S. 

Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes. 

Biochim Biophys Acta 2015; 1852(1):146-155 

DOI: 10.1016/j.bbadis.2014.11.011 


Bielarczyk H, Jankowska-Kulawy A, Höfling C, Ronowska A, Gul-Hinc S, Roßner S, Schliebs R, Pawelczyk T, Szutowicz A. 

AβPP-Transgenic 2576 Mice Mimic Cell Type-Specific Aspects of Acetyl-CoA-Linked Metabolic Deficits in Alzheimer's Disease. 

J Alzheimers Dis 2015; 48(4): 1083-1094 

DOI: 10.3233/JAD-150327 


Eschke M, Piehler D, Schulze B, Richter T, Grahnert A, Protschka M, Müller U, Köhler G, Höfling C, Roßner S, Alber G. 

A novel experimental model of Cryptococcus neoformans-related immune reconstitution inflammatory syndrome (IRIS) provides insights into pathogenesis. 

Eur J Immunol. 2015; 45: 3339-3350 

DOI: 10.1002/eji.201545689 


Kara F, Höfling C, Roßner S, Schliebs R, Van der Linden A, Groot HJM, Alia A. 

In vivo longitudinal monitoring of changes in the corpus callosum integrity during disease progression in a mouse model of Alzheimer’s disease. 

Current Alzheimer Research 2015; 12(10): 941-950 

DOI: 10.2174/1567205012666151027123728 


Wagner L, Wolf R, Zeitschel U, Roßner S, Petersén Å, Leavitt BR, Kästner F, Rothermundt M, Gärtner UT, Gündel D, Schlenzig D, Frerker N, Schade J, Manhart S, Rahfeld JU, Demuth HU, von Hörsten S. 

Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery. 

J Neurochem. 2015; 135: 1019-1037 

DOI: 10.1111/jnc.13378 



Höfling C, Indrischek H, Höpcke T, Waniek A, Cynis H, Koch B, Schilling S, Morawski M, Demuth HU, Roßner S, Hartlage-Rübsamen M. 

Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC. 

Int J Dev Neurosci. 2014; 36: 64-73 

DOI: 10.1016/j.ijdevneu.2014.05.008 


Keihan Falsafi S, Roßner S, Ghafari M, Groessl M, Morawski M, Gerner C, Lubec G. 

Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets. 

Amino Acids 2014; 46(1): 223-233 

DOI: 10.1007/s00726-013-1623-9 


Morawski M, Dityatev A, Hartlage-Rübsamen M, Blosa M, Holzer M, Flach K, Pavlica S, Dityateva G, Grosche J, Brückner G, Schachner M. 

Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan. 

Philos Trans R Soc Lond B Biol Sci. 2014; 369(1654): 20140046 

DOI: 10.1098/rstb.2014.0046 


Morawski M, Schilling S, Kreuzberger M, Waniek A, Jäger C, Koch B, Cynis H, Kehlen A, Arendt T, Hartlage-Rübsamen M, Demuth HU, Roßner S

Glutaminyl Cyclase in Human Cortex: Correlation with (pGlu)-Amyloid-β Load and Cognitive Decline in Alzheimer's Disease. 

J Alzheimers Dis 2014; 39: 385-400 

DOI: 10.3233/JAD-131535 


Schulz I, Engel C, Niestroj AJ, Kehlen A, Rahfeld JU, Kleinschmidt M, Lehmann K, Roßner S, Demuth HU. 

A non-canonical function of eukaryotic elongation factor 1A1: Regulation of interleukin-6 expression. 

Biochim Biophys Acta 2014; 1843: 965-975 

DOI: 10.1016/j.bbamcr.2014.01.022 


Hartlage-Rübsamen M, Waniek A, Roßner S.

Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.

Int J Dev Neurosci. 2013; 31(1): 36-45

DOI: 10.1016/j.ijdevneu.2012.10.001 


Hoffmeister A, Tuennemann J, Sommerer I, Mössner J, Rittger A, Schleinitz D, Kratzsch J, Rosendahl J, Klöting N, Stahl T, Roßner S, Paroni F, Maedler K, Kovacs P, Blüher M.

Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression.

Obesity 2013; 21: E626-E633

DOI: 10.1002/oby.20482


Morawski M, Nuytens K, Juhasz T, Zeitschel U, Seeger G, Waelkens E, Regal L, Schulz I, Arendt T, Szeltner Z, Creemers J, Roßner S.

Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons. 

Neuroscience 2013; 242: 128-139

DOI: 10.1016/j.neuroscience.2013.02.038


Kuhn P-H, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF. 

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons 

EMBO J 2012; 31(14): 3157-3168 

DOI: 10.1038/emboj.2012.173 



Hartlage-Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R, Demuth HU, Roßner S. 

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms. 

Acta Neuropathol 2011; 121(6): 705-719 

DOI: 10.1007/s00401-011-0806-2  


Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Roßner S, Schilling S, Osmand AP, Demuth HU, von Hörsten S. 

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. 

J Neurosci 2011; 31(36): 12790-12801 

DOI: 10.1523/JNEUROSCI.1794-11.2011  


Morawski M, Schulz I, Zeitschel U, Blosa M, Seeger G, Roßner S. 

Role of Prolyl Oligopeptidase in Intracellular Transport and Protein Secretion. 

CNS Neurol Disord Drug Targets 2011; 10(3): 327-332 

DOI: 10.2174/187152711794653805  


Penttinen A, Tenorio-Laranga J, Siikanen A, Morawski M, Roßner S, García-Horsman JA. 

Prolyl Oligopeptidase: A Rising Star on the Stage of Neuroinflammation Research. 

CNS Neurol Disord Drug Targets 2011; 10(3): 340-348 

DOI: 10.2174/187152711794653742  


Schilling S, Kohlmann S, Baeuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hoersten S, Roßner S, Graubner S, Demuth HU 

Glutaminyl cyclase (QC) knock out mice show mild hypothyreodism but absence of hypogonadism: implications for enzyme function and drug development. 

J Biol Chem 2011; 286(16): 14199-14208 

DOI: 10.1074/jbc.M111.229385  


Schulz I, Engel C, Niestroj AJ, Zeitschel U, Menge K, Kehlen A, Meyer A, Roßner S, Demuth HU. 

Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway. 

J Neuroinflammation 2011; 8: 86 

DOI: 10.1186/1742-2094-8-86  


Morawski M, Hartlage-Rübsamen M, Jäger C, Waniek A, Schilling S, Schwab C, McGeer PL, Arendt T, Demuth HU, Roßner S. 

Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. 

Acta Neuropathol 2010; 120(2): 195-207 

DOI: 10.1007/s00401-010-0685-y 


Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Roßner S, Lichtenthaler SF. 

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. 

EMBO J. 2010; 29: 3020-3032 

DOI: 10.1038/emboj.2010.167 


Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Roßner S, Haass C, Lichtenthaler SF. 

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. 

J Neurosci 2010; 30(26): 8974-8983 

DOI: 10.1523/JNEUROSCI.1199-10.2010 


Hartlage-Rübsamen M, Staffa K, Waniek A, Wermann M, Hoffmann T, Cynis H, Schilling S, Demuth HU, Roßner S.

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.

Int J Dev Neurosci 2009; 27: 825-835

DOI: 10.1016/j.ijdevneu.2009.08.007


Hoffmeister A, Dietz G, Zeitschel U, Mössner J, Roßner S, Stahl T.

BACE1 is a newly discovered protein secreted by the pancreas which cleaves enteropeptidase in vitro.

JOP 2009; 10(5): 501-506


Ueberham U, Lange P, Ueberham E, Brückner MK, Hartlage-Rübsamen M, Pannicke T, Rohn S, Cross M, Arendt T.

Smad2 isoforms are differentially expressed during mouse brain development and aging.

Int J Dev Neurosci 2009; 27(5): 501-510 

DOI: 10.1016/j.ijdevneu.2009.04.001


Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HJ, Roßner S. 

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer’s disease-like pathology. 

Nature Medicine 2008; 14:1106-1111 

DOI: 10.1038/nm.1872  

Buggia-Prevot V, Sevalle J, Roßner S, Checler F. 

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42. 

J Biol Chem 2008; 283(15): 10037-10047 

DOI: 10.1074/jbc.M706579200  


Herrmann P, Druckrey-Fiskaaen C, Kouznetsova E, Heinitz K, Bigl M, Cotman SL, Schliebs R. 

Developmental impairments of select neurotransmitter systems in brains of Cln3(Deltaex7/8) knock-in mice, an animal model of juvenile neuronal ceroid lipofuscinosis. 

J Neurosci Res 2008; 86(8): 1857-1870 

DOI: 10.1002/jnr.21630  


Schneider HJ, Roßner S, Pfeiffer D, Hagendorff A. 

D-ribose improves cardiac contractility and hemodynamics, and reduces expression of c-fos in the hippocampus during sustained slow ventricular tachycardia in rats.
Int J Cardiol 2008; 125(1): 49-56 

DOI: 10.1016/j.ijcard.2007.02.018  


Reimers S, Hartlage-Rübsamen M, Brückner G, Roßner S.

Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.

Eur J Neurosci 2007; 25: 2640-2648

DOI: 10.1111/j.1460-9568.2007.05514.x

Bourne KZ, Ferrari DC, Lange-Dohna C, Roßner S, Wood TG, Perez-Polo JR.

Differential regulation of BACE1 promoter activity by nuclear factor-κB in neurons and glia upon exposure to β-amyloid peptides.

J Neurosci Res 2007; 85(6): 1194-1204

DOI: 10.1002/jnr.21252


Milius D, Gröger-Arndt H, Stanchev D, Lange-Dohna C, Roßner S, Sperlagh B, Wirkner K, Illes P

Oxygen/glucose deprivation increases the integration of recombinant P2X(7) receptors into the plasma membrane of HEK293 cells.
Toxicology 2007; 238(1): 60-69

DOI: 10.1016/j.tox.2007.05.028


Yun SW, Kouznetsova E, Nitschke C, Heinitz K, Schliebs R, Gerlach M, Riederer P, Klein MA.

β-Amyloid deposition and prion infection in adult primary brain cell long-term culture model.
Biochem Biophys Res Commun. 2007; 360(3): 520-524

DOI: 10.1016/j.bbrc.2007.05.227


Heinitz K, Beck M, Schliebs R, Perez-Polo JR.

Toxicity mediated by soluble oligomers of beta-amyloid(1-42) on cholinergic SN56.B5.G4 cells.

J Neurochem 2006; 98(6): 1930-1945

DOI: 10.1111/j.1471-4159.2006.04015.x  


Nowak K, Lange-Dohna C, Zeitschel U, Günther A, Lüscher B, Robitzki A, Perez-Polo R, Roßner S.

The transcription factor Yin Yang1 is an activator of BACE1 expression.

J Neurochem 2006; 96: 1696-1707

DOI: 10.1111/j.1471-4159.2006.03692.x  


Roßner S, Sastre M, Bourne KZ, Lichtenthaler S.

Transcriptional and translational regulation of BACE1 expression – implications for Alzheimer’s disease.

Progr Neurobiol 2006; 79: 95-111

DOI: 10.1016/j.pneurobio.2006.06.001  


Sastre M, Dewachter I, Roßner S, Bogdanovic N, Rosen E, Borghgraef P, Evert B, Dumitrescu-Ozimek L, Thal D, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT.

Nonsteroidal anti-inflammatory drugs repress BACE1 gene promoter activity by activation of the peroxisome proliferator–activated receptor-g (PPARg).

Proc Natl Acad Sci USA 1 2006; 03: 443-448

DOI: 10.1073/pnas.0503839103  



Roßner S, Lange-Dohna C, Zeitschel U, Perez-Polo R.

Alzheimer’s disease β-secretase BACE1 is not a neuron-specific enzyme.

J Neurochem 2005; 92: 226-234

DOI: 10.1111/j.1471-4159.2004.02857.x  


Roßner S, Schulz I, Zeitschel U, Schliebs R, Bigl V, Demuth HU.

Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer’s disease.

Neurochem Res 2005; 30: 695-702

DOI: 10.1007/s11064-005-6863-y  

Günther A, Küppers-Tiedt L, Schneider PM, Kuhnert I, Berrouschot J, Schneider D, Roßner S.

Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia.

Eur J Neurosci 2005; 21: 3189-3194

DOI: 10.1111/j.1460-9568.2005.04151.x  


Schulz I, Zeitschel U, Rudolph T, Ruiz-Carrillo D, Rahfeld JU, Gerhartz B, Bigl V, Demuth HU, Roßner S.

Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.

J Neurochem 2005; 94: 970-979

DOI: 10.1111/j.1471-4159.2005.03237.x  

Hobohm C, Günther A, Grosche J, Roßner S, Schneider D, Brückner G.

Decomposition and long-lasting downregulation of extracellular matrix in perineuronal nets induced by focal forebrain ischemia.

J Neurosci Res 2005; 80: 539-548

DOI: 10.1002/jnr.20459  


Wenzel B, Sorger D, Heinitz K, Scheunemann M, Schliebs R, Steinbach J, Sabri O.

Structural changes of benzylether derivatives of vesamicol and their influence on the binding selectivity to the vesicular acetylcholine transporter.
Eur J Med Chem 2005; 40(12): 1197-1205

DOI: 10.1016/j.ejmech.2005.06.007  



Roßner S.

New players in old amyloid precursor protein processing pathways.

Int J Dev Neurosci 2004; 22: 467-474

DOI: 10.1016/j.ijdevneu.2004.07.004 


Roßner S, Fuchsbrunner K, Lange-Dohna C, Hartlage-Rübsamen M, Bigl V, Betz A, Reim K, Brose N.

Munc13-1-mediated vesicle priming contributes to secretory APP processing.

J Biol Chem 2004: 279: 27841-27844

DOI: 10.1074/jbc.C400122200 

Franke H, Günther A, Grosche J, Schmidt R, Roßner S, Reinhardt R, Faber-Zuschratter H, Schneider D, Illes P.

P2X7 receptor expression after ischemia in the cerebral cortex of rats.

J Neuropathol Exp Neurol 2004; 63: 686-699

DOI: 10.1093/jnen/63.7.686 


Scheunemann M, Sorger D, Wenzel B, Heinitz K, Schliebs R, Klingner M, Sabri O, Steinbach J.

Synthesis of novel 4- and 5-substituted benzyl ether derivatives of vesamicol and in vitro evaluation of their binding properties to the vesicular acetylcholine transporter site.
Bioorg Med Chem 2004; 12(6): 1459-1465

DOI: 10.1016/j.bmc.2003.12.035 



Hartlage-Rübsamen M, Zeitschel U, Apelt J, Gärtner U, Franke H, Stahl T, Günther A, Schliebs R, Penkowa M, Bigl V, Roßner S.

Astrocytic expression of the Alzheimer’s disease β-secretase (BACE) is stimulus-dependent.

Glia 2003; 41: 169-179

DOI: 10.1002/glia.10178 


Lange-Dohna C, Zeitschel U, Gaunitz F, Perez-Polo R, Bigl V, Roßner S.

Cloning and expression of the rat BACE1 promoter.

J Neurosci Res 2003; 73: 73-80

DOI: 10.1002/jnr.10639 

Beck M, Bigl V, Roßner S.

Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo.

Neurochem Res 2003; 28: 637-644

DOI: 10.1023/a:1022850113083


Bigl V, Roßner S.

Amyloid precursor protein processing in vivo - insights from a chemically-induced constitutive overactivation of protein kinase C in guinea pig brain.

Curr Med Chem 2003; 10: 871-882 

DOI: 10.2174/0929867033457692


Brückner G, Grosche J, Hartlage-Rübsamen M, Schmidt S, Schachner M.

Region and lamina-specific distribution of extracellular matrix proteoglycans, hyaluronan and tenascin-R in the mouse hippocampal formation.
J Chem Neuroanat 2003; 26(1): 37-50

DOI: 10.1016/s0891-0618(03)00036-x 


Tomaszewicz M, Roßner S, Schliebs R, Cwikowska J, Szutowicz A.

Changes in cortical acetyl-CoA metabolism after selective basal forebrain cholinergic degeneration by 192IgG-saporin.

J Neurochem 2003; 87: 318-324

DOI: 10.1046/j.1471-4159.2003.01983.x 



Zeitschel U, Schliebs R, Roßner S, Bigl V, Eschrich K, Bigl M.

Changes in activity and expression of phosphofructokinase in different rat brain regions after basal forebrain cholinergic lesion.

J Neurochem 2002; 83: 371-380

DOI: 10.1046/j.1471-4159.2002.01127.x 

Lushchekina EA, Bigl M, Apelt J, Lange-Dohna C, Roßner S, Schliebs R.

Expression of beta-Secretase mRNA in the brain of rats with immunohistochemical destruction of basal forebrain cholinergic system.
Bull Exp Biol Med 2002; 134(3): 236-240

DOI: 10.1023/a:1021564231603 

Gerlach R, Beck M, Zeitschel U, Seifert V.

MK 801 attenuates c-Fos and c-Jun expression after in vitro ischemia in rat neuronal cell cultures but not in PC 12 cells.
Neurol Res 2002; 24(7): 725-729

DOI: 10.1179/016164102101200654 


Hartlage-Rübsamen M, Apelt J, Schliebs R.

Fibrillary beta-amyloid deposits are closely associated with atrophic nitric oxide synthase (NOS)-expressing neurons but do not upregulate the inducible NOS in transgenic Tg2576 mouse brain with Alzheimer pathology.
Neurosci Lett 2001; 302(2-3): 73-76

DOI: 10.1016/s0304-3940(01)01652-4  


Hartlage-Rübsamen M, Schliebs R.

Rat basal forebrain cholinergic lesion affects neuronal nitric oxide synthase activity in hippocampal and neocortical target regions.
Brain Res 2001; 889(1-2): 155-164

DOI: 10.1016/s0006-8993(00)03128-0  


Hartlage-Rübsamen M, Schliebs R.

Sequential upregulation of cell adhesion molecules in degenerating rat basal forebrain cholinergic neurons and in phagocytotic microglial cells.
Brain Res 2001; 897(1-2): 20-26

DOI: 10.1016/s0006-8993(01)02093-5  


Roßner S, Apelt J, Schliebs R, Perez-Polo JR, Bigl V.

Neuronal and glial β-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.

J Neurosci Res 2001; 64: 437-446

DOI: 10.1002/jnr.1095  


Roßner S, Brückner MK, Bigl V.

Developmentally induced microencephalopathy in guinea pigs - embryonic glial cell activation marks selective neuronal death.

Int J Devl Neurosci 2001; 19: 313-318

DOI: 10.1016/s0736-5748(01)00015-6  


Roßner S, Mehlhorn G, Schliebs R, Bigl V.

Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology.

Eur J Neurosci 2001; 13: 269-278


Roßner S, Mendla K, Schliebs R, Bigl V.

Protein kinase Ca and β1 isoforms are regulators of a-secretory proteolytic processing of amyloid precursor protein in vivo

Eur J Neurosci 2001; 13: 1644-1648

DOI: 10.1046/j.0953-816x.2001.01525.x 


Roßner S, Beck M, Stahl T, Mendla K, Schliebs R, Bigl V.

Constitutive overactivation of protein kinase C in guinea pig brain increases -secretory APP processing without decreasing β-amyloid generation.

Eur J Neurosci 2000; 12: 3191-3200

DOI: 10.1046/j.1460-9568.2000.00211.x  


Roßner S, Schliebs R, Bigl V.

Intracerebroventricular infusion of CHO5, a rat monoclonal antibody directed against mouse low-affinity nerve growth factor receptor (p75NTR), specifically labels basal forebrain cholinergic neurons in mouse brain.

Metab Brain Disease 2000; 15: 17-27

DOI: 10.1007/BF02680011  


Bigl M, Apelt J, Luschekina E, Lange-Dohna C, Roßner S, Schliebs R.

Expression of -secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology.

Neurosci Lett 2000; 292: 107-110

DOI: 10.1016/s0304-3940(00)01452-x  


Sorger D, Schliebs R, Kämpfer I, Roßner S, Heinicke J, Dannenberg C, Georgi P.

In vivo [125I]-iodobenzovesamicol binding reflects cortical cholinergic deficiency induced by specific immunolesion of rat basal forebrain cholinergic system.

Nucl Med Biol 2000; 27: 23-31

DOI: 10.1016/s0969-8051(99)00087-6  



Hartlage-Rübsamen M, Lemke R, Schliebs R.

Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection.

J Neurosci Res 1999; 57(3): 388-398


Roßner S, Schliebs R, Bigl V.

Regulation of amyloid precursor protein catabolism by cholinergic mechanisms.

Alzheimer Actualites 1999; 143: 8-13


Roßner S, Ueberham U, Schliebs R, Perez-Polo JR, Bigl V.

Regulated secretion of amyloid precursor protein by TrkA receptor stimulation is mitogen activated protein kinase sensitive.

Neurosci Lett 1999; 271: 97-100

DOI: 10.1016/s0304-3940(99)00530-3  

Lemke R, Roßner S, Schliebs R.

Leukemia inhibitory factor expression is not induced in activated microglia and reactive astrocytes in response to rat basal forebrain cholinergic lesion.

Neurosci Lett 1999; 267: 53-56

DOI: 10.1016/s0304-3940(99)00332-8  


Reisner E, Nöldner M, Roßner S, Chatterjee SS, Bigl V, Schliebs R.

Acute effect of KA-672, a putative cognitive enhancer, on neurotransmitter receptor binding in mouse brain. Neurosci Lett 1999; 274: 187-190

DOI: 10.1016/s0304-3940(99)00725-9  

Lemke R, Hartlage-Rübsamen M, Schliebs R.

Differential injury-dependent glial expression of interleukins-1 alpha, beta, and interleukin-6 in rat brain.
Glia 1999; 27(1): 75-87


Sorger D, Kämpfer I, Schliebs R, Roßner S, Dannenberg C, Knapp WH.

Iodo-QNB cortical binding and brain perfusion: effects of a cholinergic basal forebrain lesion in the rat.

Nucl Med Biol 1999; 26: 9-16

DOI: 10.1016/s0969-8051(98)00059-6  


Roßner S, Bakinde N, Zeitschel U, Schliebs R, Bigl V.

Cerebrospinal fluid cholinesterases - Markers for loss of cholinergic basal forebrain neurons?

Int J Devl Neurosci 1998; 16: 669-673

DOI: 10.1016/s0736-5748(98)00077-x  


Roßner S, Ueberham U, Schliebs R, Perez-Polo JR, Bigl V.

Neurotrophin binding to the p75 neurotrophin receptor is required but not sufficient to mediate NGF-effects on APP secretion in PC-12 cells.

J Neural Transm 1998; Suppl 54: 279-285

DOI: 10.1007/978-3-7091-7508-8_27  


Roßner S, Ueberham U, Schliebs R, Perez-Polo JR, Bigl V.

p75NTR and TrkA receptor signaling independently regulate APP mRNA expression, isoform composition, and protein secretion in PC-12 cells.

J Neurochem 1998; 71: 757-766

DOI: 10.1046/j.1471-4159.1998.71020757.x  


Roßner S, Ueberham U, Schliebs R, Perez-Polo JR, Bigl V.

The regulation of APP metabolism by cholinergic mechanisms and neurotrophin receptor signaling.

Progr Neurobiol 1998; 56: 541-569

DOI: 10.1016/s0301-0082(98)00044-6  

Lemke R, Härtig W, Roßner S, Bigl V, Schliebs R.

Interleukin-6 is not expressed in activated microglia and in reactive astrocytes in response to lesion of rat basal forebrain cholinergic system as demonstrated by combined in situ hybridization and immunocytochemistry.

J Neurosci Res 1998; 51: 223-236

DOI: 10.1002/(SICI)1097-4547(19980115)51:2<223::AID-JNR11>3.0.CO;2-9  


Mehlhorn G, Löffler T, Apelt J, Roßner S, Urabe T, Hattori N, Nagamatsu S, Bigl V, Schliebs R.

Glucose metabolism in cholinoceptive cortical rat brain regions after basal forebrain cholinergic lesion.

Int J Devl Neurosci 1998; 16: 675-690

DOI: 10.1016/s0736-5748(98)00078-1  

Brauer K, Seeger G, Härtig W, Roßner S, Poethke R, Schliebs R, Brückner G, Bigl V.

Electron microscopic evidence for a cholinergic innervation of GABAergic parvalbumin-immunoreactive neurons in the rat medial septum.

J Neurosci Res 1998; 54: 248-253

DOI: 10.1002/(SICI)1097-4547(19981015)54:2<248::AID-JNR12>3.0.CO;2-0  


Nitsch RM, Roßner S, Albrecht C, Mayhaus M, Endrich J, Schliebs R, Wegner M, Arendt T, von der Kammer H.

Muscarinic acetylcholine receptors activate acetylcholinesterase gene promoter.

J Neurophysiol 1998; 92: 257-264

DOI: 10.1016/s0928-4257(98)80029-6  


Roßner S.

Cholinergic immunolesions by 192IgG-saporin - a useful tool to simulate pathogenic aspects of Alzheimer’s disease.

Int J Devl Neurosci 1997; 15: 835-850

DOI: 10.1016/s0736-5748(97)00035-x  


Roßner S, Schliebs R, Härtig W, Perez-Polo JR, Bigl V.

Selective induction of c-Jun and NGF in reactive astrocytes after cholinergic degenerations in rat basal forebrain. NeuroReport 1997; 8: 2199-2202

DOI: 10.1097/00001756-199707070-00022  


Roßner S, Ueberham U, Yu J, Kirazov L, Schliebs R, Perez-Polo R, Bigl V.

In vivo regulation of amyloid precursor protein secretion in rat neocortex by cholinergic activity.

Eur J Neurosci 1997; 9: 2125-2134

DOI: 10.1111/j.1460-9568.1997.tb01379.x  


Roßner S, Wörtwein G, Yu J, Gu Z, Schliebs R, Bigl V, Perez-Polo JR.

Cholinergic control of nerve growth factor in adult rats - evidence from cortical cholinergic deafferentation and chronic drug treatment.

J Neurochem 1997; 69: 947-953

DOI: 10.1046/j.1471-4159.1997.69030947.x  

Apelt J, Schliebs R, Beck M, Roßner S, Bigl V.

Expression of amyloid precursor protein mRNA isoforms in rat brain is differntially regulated during postnatal maturation and by cholinergic activity.

Int J Devl Neurosci 1997; 15: 95-112

DOI: 10.1016/s0736-5748(96)00073-1  


Brückner MK, Roßner S, Arendt T.

Differential changes in the expression of AMPA receptor genes in rat brain after chronic exposure to ethanol: an in situ hybridization study.

J Brain Res 1997; 38: 369-376


Heider M, Schliebs R, Roßner S, Bigl V.

Basal forebrain cholinergic immnunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of a2- and b-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals.

Neurochem Res 1997; 22: 957-966

DOI: 10.1023/a:1022418708293  


Seeger G, Härtig W, Roßner S, Schliebs R, Brückner G, Bigl V, Brauer K.

Electron microscopic evidence for microglial phagocytic activity and cholinergic cell death after administration of the immunotoxin 192IgG-saporin in rat.

J Neurosci Res 1997; 48: 465-476

DOI: 10.1002/(sici)1097-4547(19970601)48:5<465::aid-jnr7>3.0.co;2-c  


Hartlage-Rübsamen M, Rubel EW.

Influence of mitochondrial protein synthesis inhibition on deafferentation-induced ultrastructural changes in nucleus magnocellularis of developing chicks.
J Comp Neurol 1996; 371(3): 448-460

DOI: 10.1002/(SICI)1096-9861(19960729)371:3<448::AID-CNE7>3.0.CO;2-2 


Roßner S, Yu J, Pizzo D, Werrbach-Perez K, Schliebs R, Bigl V, Perez-Polo JR.

Effects of  intraventricular transplantation of NGF-secreting cells on basal forebrain cholinergic neurons after partial immunolesion.

J Neurosci Res 1996; 45: 40-56

DOI: 10.1002/(SICI)1097-4547(19960701)45:1<40::AID-JNR4>3.0.CO;2-H 


Schliebs R, Roßner S, Bigl V.

Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction.

Progr Brain Res 1996; 109: 253-264

DOI: 10.1016/s0079-6123(08)62109-3 


Zeitschel U, Bigl M, Eschrich K, Bigl V.

Cellular distribution of 6-phosphofructo-1-kinase isoenzymes in rat brain.
J Neurochem 1996; 67(6): 2573-2580

DOI: 10.1046/j.1471-4159.1996.67062573.x 



Roßner S, Härtig W, Schliebs R, Brückner G, Brauer K, Perez-Polo JR, Wiley RG, Bigl V.

192IgG-saporin immunotoxin-induced loss of cholinergic cells differentially activates microglia in rat basal forebrain nuclei.

J Neurosci Res 1995; 41: 335-346

DOI: 10.1002/jnr.490410306  


Roßner S, Schliebs R, Bigl V.

192IgG-saporin-induced immunotoxic lesions of cholinergic basal forebrain system differentially affect glutamatergic and GABAergic markers in cortical rat brain regions.

Brain Res 1995; 696: 165-176

DOI: 10.1016/0006-8993(95)00844-g  


Roßner S, Schliebs R, Härtig W, Bigl V.

192IgG-saporin-induced immunotoxic lesion of cholinergic basal forebrain system: neurochemical effects on cholinergic neurotransmission in rat cerebral cortex and hippocampus.

Brain Res Bull 1995; 38: 371-381

DOI: 10.1016/0361-9230(95)02002-9  


Roßner S, Schliebs R, Perez-Polo JR, Wiley RG, Bigl V.

Differential changes in cholinergic markers from selected brain regions after specific immunolesion of rat cholinergic basal forebrain system.

J Neurosci Res 1995; 40: 31-43

DOI: 10.1002/jnr.490400105

Garden GA, Hartlage-Rübsamen M, Rubel EW, Bothwell MA.

Protein masking of a ribosomal RNA epitope is an early event in afferent deprivation-induced neuronal death.
Mol Cell Neurosci 1995; 6(3): 293-310

DOI: 10.1006/mcne.1995.1023  



Roßner S, Kumar A, Witzemann V, Schliebs R.

Development of laminar expression of the m2 muscarinic cholinergic receptor gene in rat visual cortex and the effect of monocular visual deprivation.

Dev Brain Res 1994; 77: 55-61; Erratum 78: 796-797

DOI: 10.1016/0165-3806(94)90213-5  


Roßner S, Perez-Polo JR, Wiley RG, Schliebs R, Bigl V.

Differential expression of immediate early genes in distinct layers of rat cerebral cortex after selective immunolesion of the forebrain cholinergic system.

J Neurosci Res 1994; 38(3): 282-293

DOI: 10.1002/jnr.490380306  


Roßner S, Schliebs R, Bigl V.

Ibotenic acid lesion of nucleus basalis magnocellularis differentially affects cholinergic, glutamatergic, and GABAergic markers in cortical rat brain regions.

Brain Res 1994; 668: 85-99

DOI: 10.1016/0006-8993(94)90514-2  


Schliebs R, Feist T, Roßner S, Bigl V.

Receptor function in cortical rat brain regions after lesion of Nucleus Basalis.

J Neural Transm Suppl 1994; 44: 195-208

DOI: 10.1007/978-3-7091-9350-1_15  


Schliebs R, Roßner S, Kumar A, Bigl V.

Muscarinic acetylcholine receptor subtypes in rat visual cortex - a comparative study using quantitative receptor autoradiography and in situ hybridization.

Indian J Exper Biol 1994; 32: 25-30 



Roßner S, Kues W, Witzemann V, Schliebs R.

Laminar expression of m1-, m3-, and m4-muscarinic cholinergic receptor genes in the developing rat visual cortex using in situ hybridization histochemistry. Effect of monocular visual deprivation.

Int J Devl Neurosci 1993; 11: 369-378

DOI: 10.1016/0736-5748(93)90008-2  


Roßner S, Kumar A, Kues W, Witzemann V, Schliebs R.

Differential laminar expression of AMPA receptor genes in the developing rat visual cortex using in situ hybridization histochemistry. Effect of visual deprivation.

Int J Devl Neurosci 1993; 11: 411-424

DOI: 10.1016/0736-5748(93)90015-6 


Fischer U, Zeitschel U, Jakubke HD.

Chymotrypsin-catalyzed peptide synthesis in an acetonitrile-water-system: studies on the efficiency of nucleophiles.
Biomed Biochim Acta 1991; 50(10-11): S131-135